What do Keratic precipitates indicate?
What do Keratic precipitates indicate?
Keratic precipitates (KPs) are corneal endothelial deposits that are frequently observed in association with anterior segment inflammation. These precipitates are formed by the aggregation of polymorphonuclear cells, lymphocytes, and epitheloid cells.
What is the importance of detecting Keratic precipitates?
In conclusion, IVCM plays a potentially important role in identification of underlying mechanisms in complex forms of uveitis and can be used as an adjunctive tool for differentiating granulomatous from nongranulomatous inflammation. Smooth-rounded KPs are strongly suggestive of granulomatous inflammation.
Do Keratic precipitates stain with fluorescein?
Slit lamp shows anterior chamber reaction manifested by · Inflammatory cells · Flare (protein leakage) · Keratic precipitates. Test with fluorescein stain to rule out corneal abrasion and herpes simplex dendrite.
What is cell and flare?
“Cell” is the individual inflammatory cells while “flare” is the foggy appearance given by protein that has leaked from inflamed blood vessels. This finding is commonly seen with uveitis, iritis, and after surgery … and actually seeing it can be challenging for the beginning ophthalmology residents.
Why is mutton-fat KP?
KP are collections of inflammatory cells on the corneal endothelium. When these coalesce and become large with a yellowish color, they are described as mutton-fat KP. These are typically associated with granulomatous inflammation.
What is negative fluorescein staining?
Negative staining occurs in places where the fluorescein dye runs off elevations in the cornea and it looks darker than the surrounding areas (Figures 3A and 3B). Negative staining can often highlight even very mild corneal irregularities from EBMD and SND.
What is rose bengal staining?
Rose Bengal is a mildly toxic bright red stain that is adsorbed to and absorbed by compromised epithelial cells, mucus and fibrous tissue (Figure 16.2).
How are keratic precipitates formed in the corneal?
Keratic precipitates (KPs) are corneal endothelial deposits that are frequently observed in association with anterior segment inflammation. These precipitates are formed by the aggregation of polymorphonuclear cells, lymphocytes, and epitheloid cells.
How are keratic precipitates evaluated in uveitis patients?
In this prospective study “keratic precipitates” (KP) in different types of uveitis were examined in different stages of the disease process and the endothelial changes occurring in the vicinity of the KP were evaluated in comparison with the endothelium of the uninvolved eye. METHODS 13 patients with active unilateral uveitis were recruited.
How is Keratic precipitate imaged in ivcm and SLE?
The association of keratic precipitate (KP) appearances as imaged with slit-lamp examination (SLE) and in vivo confocal microscopy (IVCM). Only primary KPs as imaged with IVCM have been included. The Roman numbers at the top of the bars refer to the KP types as imaged with IVCM.
What are the characteristics of the KP on a slit lamp?
On slit lamp examination the characteristics of the KP—number, size, (fine or mutton fat), nature of the KP (fresh versus old), pigmentation, and their position on the endothelium—were recorded in a diagrammatic pattern (Table 1 ). Any other deposits, pigments on the endothelium and other corneal abnormalities were also noted.