Why is losartan uricosuric?
Why is losartan uricosuric?
The angiotensin II receptor blocker losartan lowers serum concentration of urate (Sur) in hypertensive subjects through a significant uricosuric action. This effect has been reported to result from the inhibition of urate/anion transport in brush-border cells of the renal proximal tubules.
Which ARB is uricosuric?
Candesartan and irbesartan were the other ARBs found in the literature that were compared to losartan for their potential uricosuric effects.
What are uricosuric drugs?
Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the kidney.
Is allopurinol a uricosuric?
The action of ZYLOPRIM (allopurinol) differs from that of uricosuric agents, which lower the serum uric acid level by increasing urinary excretion of uric acid.
Can losartan cause high uric acid?
Similarly, losartan also increases the amount of uric acid excreted from the body. The drug can reduce uric acid levels in the blood by up to 25 percent.
Can Valsartan cause high uric acid?
Some studies have shown a significant increase in uric acid serum levels caused by Valsartan.
Which ARB is best for erectile dysfunction?
The most investigated ARBs in patients with ED are valsartan, irbesartan and losartan; the latter two have also been studied in coexisting metabolic syndrome and DM. Irbesartan also showed beneficial effects in patients with ED after prostatectomy.
Which ARB is most potent?
Irbesartan has one of the highest bioavailabilities among the ARBs. Irbesartan also exhibits nearly linear dose response with a plateau at 300mg (14, 17, 34). Telmisartan is the longest acting angiotensin II receptor blocker in the market with a mean half-life of 24 hours.
Is aspirin a uricosuric agent?
At lower doses, aspirin and other salicylates are in fact anti-uricosuric. Taking aspirin or other salicylates can increase plasma uric acid levels and increase the risk of gout. Aspirin and other salicylates can also interfere with the action of uricosuric drugs prescribed for the treatment of gout.
When are uricosuric drugs used?
Uricosuric agents lower uric acid levels by inhibiting renal tubular reabsorption of uric acid, thereby increasing net renal excretion of uric acid. These agents increase the risk of renal stones, with about a 9-10% risk for probenecid. They should not be started during an attack of acute gouty arthritis.
What are the side effects of allopurinol 100mg?
The more common side effects of allopurinol oral tablet can include:
- skin rash.
- diarrhea.
- nausea.
- changes in your liver function test results.
- gout flare-up (if you have gout)
What are the side effects of zyloric?
Side Effects of Zyloric 100 Tablet 10’s
- Upset stomach.
- Diarrhea.
- Nausea.
- Skin rash.
- Drowsiness.
- Feeling or being sick.