Which is better clopidogrel or prasugrel?

Which is better clopidogrel or prasugrel?

In clinical studies, prasugrel has consistently demonstrated greater and more rapid platelet inhibition than clopidogrel in healthy subjects, patients with stable coronary artery disease (CAD) and acute coronary syndromes, and those undergoing PCI.

Is clopidogrel used for ACS?

An important part of the therapy management of acute coronary syndrome (ACS) consists of antiplatelet drugs. Whereas the administration of acetylsalicylic acid (ASA) is well established, the guidelines recommend the additive use of clopidogrel in patients with ACS without persisting ST-elevation.

When do you use prasugrel over clopidogrel?

Guidelines recommend the use of the stronger P2Y12 inhibitors, ticagrelor or prasugrel, over clopidogrel in patients with acute coronary syndrome, unless there is an excessive risk of bleeding.

Is clopidogrel same as prasugrel?

Clopidogrel and Effient (prasugrel) are antiplatelet drugs used for preventing strokes, heart attacks, and death in individuals who have had a previous stroke, unstable angina, heart attack, or have peripheral arterial disease (PAD). A brand name for clopidogrel is Plavix.

What are the side effects of taking clopidogrel?

The main side effect of clopidogrel is bleeding more easily than normal. You may have nosebleeds, heavier periods, bleeding gums or bruising. You can drink alcohol with clopidogrel. But do not drink too much while taking this medicine.

Which is better Plavix or Effient?

A previous trial of more than 13,000 ACS patients who were about to receive stents found that Effient was about 20 percent more effective than Plavix in preventing death, heart attacks and stroke. However, Effient also resulted in more cases of fatal bleeding.

Can you take prasugrel on an empty stomach?

Prasugrel comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take prasugrel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Which is better prasugrel or clopidogrel for ACS?

Use of prasugrel in diabetic patients with PCI-treated ACS was lower than in non-diabetics despite their high-risk profile and the severity of their clinical presentation. In diabetics, prasugrel was associated with a lower adjusted risk of 90-day death compared with clopidogrel.

Which is better for ACS Plavix or ticagrelor?

This typically consists of aspirin and an adenosine diphosphate receptor antagonist. It is fairly well understood that prasugrel and ticagrelor provide greater, and more rapid platelet inhibition than clopidogrel (i.e. Plavix) [5] [6]. Both ticagrelor and prasurgel have a class I recommendation for use in ACS with or without ST-segment elevation.

How often do prasugrel and ticagrelor occur in patients?

A total of 4018 patients underwent randomization. A primary end-point event occurred in 184 of 2012 patients (9.3%) in the ticagrelor group and in 137 of 2006 patients (6.9%) in the prasugrel group (hazard ratio, 1.36; 95% confidence interval [CI], 1.09 to 1.70; P=0.006).

Which is better for platelet inhibition clopidogrel or ticagrelor?

In the Platelet Inhibition and Patient Outcomes (PLATO) trial ticagrelor was superior to clopidogrel in patients who underwent PCI and those who were only medically managed.