What is thiamine used for?
What is thiamine used for?
About thiamine Thiamine, also known as thiamin or vitamin B1, is one the of B vitamins. Thiamine helps to turn food into energy to keep the nervous system healthy. Your body is not able to make thiamine for itself.
Is thiamine pH sensitive?
Abstract. Thiamine (vitamin B1), an essential water-soluble vitamin, exists as free and phosphorylated vitamers. All vitamers are sensitive to pH, heat, UV, and oxidation, making thiamine unstable.
Why is thiamine unstable under alkaline conditions?
Thiamine is stable under acidic conditions, but is labile in alkaline conditions with the opening of the thiazole ring to yield the thiol form. With further increase in pH, its behavior is complex, passing through an uncharged pseudobase intermediate to yield its negatively charged thiol form (pKa2≈9.2) (Figure 1).
What fluorometric procedure could be used to determine thiamine in the vitamin tablets?
The determination of thiamine by kinetic fluo- rescence involves the conversion of thiamine to fluorescent thiochrome, during which changes in fluorescent are monitored. Ryan and Ingle, who developed the fluorometric reaction-rate method for thiamine determination, found Hg2+ to be the most suitable oxidizing agent.
Is thiamine used for alcoholics?
Thiamine has no effect on the symptoms or signs of alcohol withdrawal or on the incidence of seizures or DTs. Routine use of thiamine is recommended because the development of Wernicke encephalopathy or Wernicke-Korsakoff syndrome is disastrous in these patients and can remain unrecognized.
Why is thiamine unstable?
[citation needed] It is unstable when exposed to ultraviolet light[9] and gamma irradiation. Thiamin is found in a wide variety of processed and whole foods, with edible seeds, legumes, rice and processed foods, such as breakfast cereals, having among the highest contents.
Is thiamine unstable?
Thiamin (vitamin B1) is one of the most unstable B vitamins. Baking, pasteurization, or boiling of foods fortified with thiamin can reduce its content by up to 50 percent. The stability of thiamin during storage depends greatly on the moisture content of the food.
Is thiamine a fluorescent?
While thiamine is visible in the UV range, its relatively common wavelength for absorbance (λ max = 242 nm) and low extinction coefficient do not lend to specific or sensitive analyses. This product of oxidation is highly fluorescent with excitation and emission wavelengths of 360 nm and 450 nm, respectively.
What is thiamine chloride hydrochloride?
Thiamine Hydrochloride is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Thiamine hydrochloride is a hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.