What is the effect of SRY?

What is the effect of SRY?

Normal Function. Collapse Section. The SRY gene provides instructions for making a protein called the sex-determining region Y protein. This protein is involved in male-typical sex development, which usually follows a certain pattern based on an individual’s chromosomes.

Do males have SRY?

Ambiguous Genitalia The majority of 46,XX males are found to carry the SRY gene, have normal male genitalia, and often present with infertility. In most instances, the SRY gene is located on an X chromosome due to illegitimate recombination between the X and Y chromosomes.

How does the SRY gene influence Behaviour?

The Y-linked gene SRY initiates male development in mammals through a pathway of gene activity leading to testis development. Because males tend to be more aggressive than females, and androgens are often blamed for this, SRY can be thought of as a contributor to such behaviour.

What happens if the SRY gene is not activated properly?

When the SRY gene isn’t working, the resulting condition is called Swyer syndrome, or XY gonadal dysgenesis. Individuals with this condition are genetically male (XY), but look female. carry children. There are also XY females who have a working SRY gene on the Y chromosome.

What triggers the SRY gene?

SRY may have arisen from a gene duplication of the X chromosome bound gene SOX3, a member of the Sox family. This duplication occurred after the split between monotremes and therians. Monotremes lack SRY and some of their sex chromosomes share homology with bird sex chromosomes.

Do females have SRY gene?

However the role for other autosomal and X-linked genes in testis determination is evident by the presence of a normal SRY gene in the majority of females with 46,XY pure gonadal dysgenesis and the lack of SRY in a minority of males with 46,XY maleness.

Can you remove the SRY gene?

A large deletion 5′ of SRY has been reported in a patient (NV) and leads to streak gonads and external female genitalia (McElreavey et al., 1992). This deletion may remove almost the entire region between SRY and RPS4Y1.