What is extensive ductal carcinoma in situ?

What is extensive ductal carcinoma in situ?

Ductal carcinoma in situ (DCIS) means the cells that line the milk ducts of the breast have become cancer, but they have not spread into surrounding breast tissue. DCIS is considered non-invasive or pre-invasive breast cancer.

Is ductal carcinoma in situ cancer?

Ductal carcinoma in situ (DCIS) is the presence of abnormal cells inside a milk duct in the breast. DCIS is considered the earliest form of breast cancer. DCIS is noninvasive, meaning it hasn’t spread out of the milk duct and has a low risk of becoming invasive.

Is ductal carcinoma in situ benign?

If these abnormal cells, which are uncontrollably growing, stay inside the duct, they are referred to as Ductal Carcinoma In-Situ (DCIS). They are ductal cells that have become malignant, but they have remained in their original place (in-situ) and are thus a noninvasive cancer.

What is extensive intraductal carcinoma?

Extensive intraductal component (EIC) in breast imaging evaluation is the pathological description where an invasive ductal carcinoma has a prominent intraductal component within it or if there is intraductal carcinoma, DCIS is present within sections of normal adjacent tissue.

What does positive for extensive intraductal component mean?

Introduction. An extensive intraductal component (EIC) is found in 30%–40% of all invasive breast carcinomas (1). It is defined as the presence of 25% or more intraductal neoplasia in invasive breast carcinoma (2).

Is ductal carcinoma in situ aggressive?

Grade 3 or even Grade 2 DCIS is a more aggressive form of DCIS. The most aggressive forms of DCIS may already be associated with “microinvasion”, very small areas that show movement of these cells out of the duct and into the surrounding breast tissue. Surgery is always recommended for these more aggressive forms.

What is intraductal component?

Abstract. The extensive intraductal component (EIC) of primary breast carcinoma is a special spread pattern observed in the breast. Extensive intraductal component may extend diffusely over the entire breast. Therefore, EIC is considered to be an important risk factor for local recurrence in breast-conserving therapy.

Is it really duct carcinoma in situ?

Although ductal carcinoma in situ (DCIS) is a non-obligate precursor to ipsilateral invasive breast cancer (iIBC), most DCIS lesions remain indolent. Hence, overdiagnosis and overtreatment of DCIS is a major concern. There is an urgent need for prognostic markers that can distinguish harmless from potentially hazardous DCIS.

What causes invasive ductal carcinoma?

In rare cases, the causes of invasive ductal carcinoma have been traced to inherited attributes, such as mutations of the: Breast cancer gene 1 (BRCA1), a tumor suppressor gene. Breast cancer gene 2 (BRCA2), a tumor suppressor gene.

Is chemotherapy needed for ductal carcinoma?

The doctors usually recommend chemo for folks who have invasive ductal carcinoma which has spread to the nodes because it usually gives you better odds. There is some discussion currently going on in the research that is wondering if this is always true.

Is carcinoma in situ considered internal cancer?

Ductal carcinoma in situ (DCIS) is non-invasive breast cancer. Ductal means that the cancer starts inside the milk ducts, carcinoma refers to any cancer that begins in the skin or other tissues (including breast tissue) that cover or line the internal organs, and in situ means “in its original place.”