Helpful tips

What enzyme metabolizes acetaminophen?

What enzyme metabolizes acetaminophen?

Acetaminophen (APAP) is extensively used as an analgesic and antipyretic drug. APAP is partly metabolized to N-acetyl-p-benzoquinone imine, a reactive metabolite, by cytochrome P450 (CYP) 1A2, 2E1 and 3A4.

Is acetaminophen a CYP450 inhibitor?

Cytochrome P450-dependent oxidation of acetaminophen results in the formation of the toxic N-acetyl-p-benzoquinone-imine (NAPQI). Although cimetidin is used in the therapy of acetaminophen overdose as an inhibitor of cytochrome P450, it is not able to reduce NAPQI formation.

What are the contraindications of acetaminophen?

Contraindications to the use of acetaminophen include hypersensitivity to acetaminophen, severe hepatic impairment, or severe active hepatic disease.

What does it mean when a drug is an inducer?

An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme. It is the opposite of an enzyme repressor.

Why is NAPQI toxic?

Mechanism and antidote NAPQI becomes toxic when GSH is depleted by an overdose of acetaminophen, Glutathione is an essential antidote to overdose. Glutathione conjugates to NAPQI and helps to detoxify it.

What do you need to know about Breuss cancer cure?

The core of the Breuss Cancer Cure is a rigid diet consisting of a 42-day fast in combination with special vegetable juices and teas. Additional recommendations are included, for instance, to avoid so-called water veins. Rudolph Breuss was born in Austria in 1899. He first worked as an electrician, and later as a naturopath.

Who was Rudolf Breuss and what did he do?

Born in 1949, Rudolf Breuss was a naturopath from Austria who worked on finding an alternative cancer treatment all his life.

What kind of cancer does Rudolf Breuss treat?

According to many reports, Breuss has successfully treated more than 2000 patients that had various diseases such as breast cancer, brain tumors, laryngeal (throat) cancer, lung cancer, advanced liver cancer, bone cancer, intestinal cancer, terminal ovarian cancer.

How to use Rudolf Breuss’s famous juice recipe?

In combination with the juice formula, Breuss recommends various herbal teas to enhance its cleansing effects. Put all the ingredients in a juicer, one at a time. Pour the expressed juice into a glass and drink slowly over a short period of time. Make sure to regularly move your bowels to avoid toxins backing up in you.