What does S6K1 do?
The mTORC1-S6K1 pathway regulates multiple cellular functions including cell cycle, apoptosis, glucose metabolism, protein synthesis and autophagy. This pathway has also been identified as one of the critical regulators of HSC and AML cells.
What is p70S6K function?
The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulate cell growth by inducing protein synthesis components. We purified membrane-based p70S6K as a kinase responsible for site-specific phosphorylation of BAD, which inactivates this proapoptotic molecule.
Does exercise increase mTOR?
Resistance Exercise and Muscular Effects. In skeletal muscle, resistance exercise causes an increase in muscle size and strength via mTOR activation.
How do I stimulate mTOR?
Exercise has been shown to increase intracellular levels of the phospholipid PA, and PA activates mTOR signaling. Resistance exercise and protein ingestion stimulate MPS and are synergistic when protein consumption occurs before or after resistance exercise. Protein consists of individual amino acids.
How is autophagy regulated by rapamycin / Akt / p70S6K?
In many cases, autophagy is regulated by the phosphatidylinositol 3-phosphate kinase/AKT/mammalian target of rapamycin/p70 ribosomal protein S6 kinase (PI3K/AKT/mTOR/p70S6K) signaling pathway. However, whether this signaling pathway is involved in Aβ-induced autophagy in neuronal cells is not known.
What is the role of Aβ in autophagy?
Aβ plays an important role in this autophagic system. In many cases, autophagy is regulated by the phosphatidylinositol 3-phosphate kinase/AKT/mammalian target of rapamycin/p70 ribosomal protein S6 kinase (PI3K/AKT/mTOR/p70S6K) signaling pathway.
How is Aβ25-35 related to the mTOR pathway?
Aβ25-35 induced autophagosome formation, the conversion of microtubule-associated protein light chain 3 (LC3), and the suppression of the mTOR pathway both in vitro and in vivo. Furthermore, Aβ25-35 impaired the learning abilities of C57 mice.