What does prostaglandin F2 alpha do?
Prostaglandin F2-alpha(PGF-2 alpha) is a stable prostaglandin that stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction (tightening) in some blood vessels. As a pharmaceutical, the generic name of PGF-2 alpha is dinoprost.
Why is prostaglandin used in PPH?
Prostaglandin (PG) agents, as second-line uterotonics, are widely used in contemporary obstetric practice . PGs have strong uterotonic properties, and such agents may be used within obstetrics and gynecology for the purpose of cervical ripening, termination of pregnancy, induction of labor, and PPH [15, 16].
What is the effect of prostaglandin F2 alpha on the reproductive system?
Administration (3 mg/kg body weight/day, for 21 days) of prostaglandin F2 alpha (PGF2 alpha) caused marked suppression of spermatogenesis and significant reduction in the weights of the testis, epididymis and accessory sex glands.
Where does prostaglandin F2 alpha come from?
Prostaglandin is an eicosanoid that is derived from unsaturated 20-carbon fatty acids, such as arachidonic acid, through the cyclooxygenase pathway.
How do you prevent postpartum hemorrhage?
The most effective strategy to prevent postpartum hemorrhage is active management of the third stage of labor (AMTSL). AMTSL also reduces the risk of a postpartum maternal hemoglobin level lower than 9 g per dL (90 g per L) and the need for manual removal of the placenta.
What is uterine Atony?
Atony of the uterus, also called uterine atony, is a serious condition that can occur after childbirth. It occurs when the uterus fails to contract after the delivery of the baby, and it can lead to a potentially life-threatening condition known as postpartum hemorrhage.
What does PGF2A stand for?
Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
What do prostaglandins do?
The prostaglandins are a group of lipids made at sites of tissue damage or infection that are involved in dealing with injury and illness. They control processes such as inflammation, blood flow, the formation of blood clots and the induction of labour.
What structure does prostaglandin f2alpha travel through in order to leave the uterus?
During luteolysis, PGF(2alpha) is synthesized and released from the endometrium in a pulsatile pattern. The unique structure of the vascular utero-ovarian plexus (UOP) allows transport of luteolytic PGF(2alpha) pulses directly from the uterus to the ovary, thus bypassing the systemic circulation.
How are prostaglandins used to treat postpartum haemorrhage?
Prostaglandins for preventing postpartum haemorrhage. If the womb does not contract, postpartum haemorrhage (heavy bleeding) can occur, which can be life threatening. A prostaglandin, oxytocin and ergometrine are all drugs that cause contractions of the womb (uterotonics). This review of 72 randomised controlled trials, involving 52,678 women,…
When to use misoprostol instead of prostaglandin?
Prostaglandins have mainly been used for postpartum haemorrhage (PPH) when other measures fail. Misoprostol, a new and inexpensive prostaglandin E1 analogue, has been suggested as an alternative for routine management of the third stage of labour. To assess the effects of prophylactic prostaglandin use in the third stage of labour.
Which is better for haemorrhage oxytocin or prostaglandin?
This review of 72 randomised controlled trials, involving 52,678 women, found that oral or sublingual prostaglandin (misoprostol) is effective in reducing severe haemorrhage after giving birth and the need for blood transfusions. Misoprostol is not as effective as oxytocin and has more side-effects.
Where does the blood from a postpartum haemorrhage come from?
Postpartum haemorrhage due to other than trauma arises from the placental bed which is obviously inside the uterus. The blood supply comes from outside the uterus and traverses the myometrium. Primary haemostasis from the placental bed is due to compression of the uterine vessels as they pass through the myometrium.