What does high apolipoprotein A1 indicate?

What does high apolipoprotein A1 indicate?

Apolipoprotein A1 (ApoA1) is the primary protein component of high-density lipoprotein (HDL). Elevated ApoB and decreased ApoA1 are associated with increased risk of cardiovascular disease.

What is the function of apo A1?

As a major component of the high-density lipoprotein complex (protective “fat removal” particles), apo A1 helps to clear fats, including cholesterol, from white blood cells within artery walls, making the WBCs less likely to become fat overloaded, transform into foam cells, die and contribute to progressive atheroma.

What is apolipoprotein A1 low?

A low Apo-A1 level indicates an increased risk of cardiovascular disease, especially in the presence of an elevated apolipoprotein B (Apo-B) level. Other factors that are associated with low Apo A1 level include the following: Chronic liver disease. Chronic kidney disease.

Where is apo A1 produced?

High-density lipoprotein is produced in the liver and intestine. ATP-binding cassette A-1 (ABCA1) adds phospholipids and some cholesterol to apo A1. This forms a primordial or nascent HDL, which has very low cholesterol.

Is A1 High apolipoprotein good?

High levels of apo A-I is considered protective and can be independent of HDL levels. There are some genetic disorders that lead to deficiencies in apo A-I (and therefore to low levels of HDL).

What happens if apolipoprotein is high?

Elevated levels of apo B correspond to elevated levels of LDL-C and to non-HDL-C and are associated with an increased risk of cardiovascular disease (CVD). Elevations may be due to a high-fat diet and/or decreased clearing of LDL from the blood.

What is A1 in blood test?

Get an A1C test to find out your average levels—important to know if you’re at risk for prediabetes or type 2 diabetes, or if you’re managing diabetes. The A1C test—also known as the hemoglobin A1C or HbA1c test—is a simple blood test that measures your average blood sugar levels over the past 3 months.

What is a good ApoB apoA ratio?

Results. The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%.

What is Apo level?

Apolipoprotein A is a protein carried in HDL (“good”) cholesterol. It helps start the process for HDL to remove bad types of cholesterol from your body. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease. Apolipoprotein A levels can be measured.

How can I increase my apolipoprotein?

Increasing Apolipoprotein B Reducing alcohol consumption may help raise ApoB levels by improving liver health. In a study of 16 people, those who drank alcohol saw a decrease in their LDL-apoB levels [28]. In a study of 18 alcoholics, ApoB levels increased by 24% after they stopped drinking [29].

How can I reduce my ApoB level?

Consuming less dietary fat and cholesterol and many more fiber-rich, whole plant foods, which is essentially the Pritikin Eating Plan, will greatly reduce the amount of chylomicrons and their atherogenic, apoB-48-containing lipoproteins in the blood.

How is apolipoprotein A1 related to APOA1BP?

Apolipoprotein A1 binding precursor, a relative of APOA-1 abbreviated APOA1BP, has a predicted biochemical interaction with Carbohydrate Kinase Domain Containing Protein. The relationship between these two proteins is substantiated by cooccurance across genomes and coexpression.

What is the role of apolipoprotein A1 in schizophrenia?

Apo A-I binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. In one study, a decrease in apo A1 levels was detected in schizophrenia patients’ CSF, brain and peripheral tissues.

What is the function of the APOA1 gene?

The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body’s tissues to the liver.

What kind of HDL deficiency lacks ApoA1?

Familial HDL deficiency characterized by hypercatabolism of mature apoA-I but not proapoA-I. Arterioscler Thromb Vasc Biol. 1998 Apr;18 (4):655-64. Citation on PubMed Chambenoit O, Hamon Y, Marguet D, Rigneault H, Rosseneu M, Chimini G. Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter.