What does ER PR and HER2 mean?
ER = estrogen receptor, Her2 = human epidermal growth factor receptor 2, PR = progesterone receptor.
What does ER PR HER2-negative mean?
When a breast cancer is HER2-negative, it means that the cancerous cells do not contain high levels of the protein HER2. There are many treatment options available for this type of breast cancer, but the prognosis can vary.
How long do HER2 results take?
All invasive breast cancers are tested for HER2 levels. This is done in a hospital laboratory on a sample of breast cancer tissue removed during a biopsy or surgery. The results are usually available between one and three weeks later.
Is ER positive breast cancer aggressive?
The estrogen activation of ER in ER-positive breast cancers enhances their aggressiveness, while the activation of exogenously introduced ERs into aggressive ER-negative cells diminishes their aggressiveness.
What does HER2 negative mean?
When a breast cell has abnormally high levels of the HER2 gene or the HER2 protein, it is called HER2- positive. The cancer is called HER2-negative when it does not have high levels of the HER2 gene or the HER2 protein. Most patients with metastatic breast cancer have HER2-negative breast cancer.
Is HER2-positive breast cancer hereditary?
HER2-positive breast cancer is not hereditary, but some other types of gene mutations related to breast cancer are inherited. Genetic testing can tell you if you have any of the mutations currently known to increase risk for breast cancer or other cancers.
What is triple positive breast cancer?
It is possible to have breast cancer that is both HER2-positive and hormone receptor-positive. Cancer that grows because of the hormones estrogen and progesterone, and HER2, is sometimes known as triple-positive breast cancer.
What is the treatment for breast cancer?
Treatments for breast cancer include surgery as well as radiation, chemotherapy and hormonal therapy. These treatments are either local or systemic. Local treatments, such as surgery and radiation therapy, remove, destroy or control cancer cells in specific areas.