What disease does protein kinase C cause?
What disease does protein kinase C cause?
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans.
How does protein kinases form cancer?
One of the most extreme paths to the cancer development and progression is the mutations of the various genes, including kinases. The mutated kinases can become constitutively active and thus cause diverse cellular anomalies, leading to cancer initiation or growth.
What does protein kinase C do?
Protein kinase C, commonly abbreviated to PKC (EC 2.7. 11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
Is protein kinase A tumor suppressor gene?
The recent analysis of cancer-associated mutations, from diverse cancers and throughout the PKC family, revealed that PKC isozymes are generally inactivated in cancer, supporting a tumor suppressive function.
How does protein kinase C cause contraction?
PKC may also phosphorylate the actin-binding protein calponin, and thereby reverses its inhibition of actin-activated myosin ATPase, allows more actin to interact with myosin, and increases VSM contraction (Figure 1.1) [2].
Are protein kinase inhibitors chemotherapy?
Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells.
What is the function of protein kinase C?
Protein kinase C (PKC) is a family of phospholipid-dependent serine/threonine kinases that function in numerous different cell types.
Are there any drugs that inhibit protein kinase C?
Tamoxifen is a PKC inhibitor. The Protein kinase C activator ingenol mebutate, derived from the plant Euphorbia peplus, is FDA-approved for the treatment of actinic keratosis. Bryostatin 1 can act as a PKCe activator and as of 2016 is being investigated for Alzheimer’s disease.
Are there any kinase targeted therapies for cancer?
This review provides an overview of kinase-targeted drug discovery and development in relation to oncology and highlights the challenges and future potential for kinase-targeted cancer therapies. Kinases are enzymes that transfer a phosphate group to a protein while phosphatases remove a phosphate group from protein.
How does PKC play a role in cancer cells?
PKC isozymes directly or indirectly participate in diverse biological phenomena in cancer cells such as cell migration, invasion, survival, proliferation, and apoptosis. Casp, caspase; JAK, Janus kinase; Grb2, growth factor receptor-bound protein 2; SOS, son of sevenless homolog; also see abbreviations in the text.
