What class of drug is pramlintide?
What class of drug is pramlintide?
Pramlintide is in a class of medications called antihyperglycemics. It works by slowing the movement of food through the stomach. This prevents blood sugar from rising too high after a meal, and may decrease appetite and cause weight loss.
What is the mechanism of action of pramlintide?
By mimicking the actions of the naturally occurring hormone amylin, pramlintide complements insulin by regulating the appearance of glucose into the circulation after meals via three primary mechanisms of action: slowing gastric emptying, suppressing inappropriate post-meal glucagon secretion, and increasing satiety.
How is pramlintide typically administered?
SYMLIN should be administered subcutaneously immediately prior to each major meal (≥250 kcal or containing ≥30 grams of carbohydrate). SYMLIN should be at room temperature before injecting to reduce potential injection site reactions. Each SYMLIN dose should be administered subcutaneously into the abdomen or thigh.
How is pramlintide excreted?
Pramlintide does not extensively bind to blood cells or albumin (approximately 40% of the drug is unbound in plasma). Metabolized primarily by the kidneys. Pramlintide is metabolized primarily by the kidneys.
When do you use pramlintide?
Pramlintide is usually given just before each major meal. If you skip a meal, you should also skip your pramlintide dose. Use a different place on your stomach or thigh each time you give the injection. Inject your insulin in a separate skin area.
How do you shoot a pramlintide?
How do you use pramlintide?
What is the function of amylin?
Amylin is a peptide hormone that is cosecreted with insulin from the pancreatic β-cell and is thus deficient in diabetic people. It inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.
Where do you inject pramlintide?
This medicine is given as a shot under the skin of your stomach or upper thigh. Inject pramlintide at a site that is more than 2 inches away from your insulin injection. Never inject insulin and pramlintide in the same site. When you first start using this medicine, you will need to adjust your insulin dose.
When should you take pramlintide?
Pramlintide is usually given just before each major meal. If you skip a meal, you should also skip your pramlintide dose. Use a different place on your stomach or thigh each time you give the injection.
How do you take pramlintide?
What is the brand name for pramlintide?
Pramlintide (trade name Symlin) is an injectable amylin analogue drug for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals (now a wholly owned subsidiary of AstraZeneca).
Where does pramlintide come from in the body?
Pramlintide is a synthetic soluble form of the naturally occurring hormone, amylin, which is co-secreted with insulin from the β cell. The pharmacologic effects of amylin are complementary to insulin in that they inhibit the inappropriate release of postprandial glucagon and slow gastric emptying.
How is pramlintide used in the treatment of diabetes?
Pramlintide is an analogue of amylin and has an action similar to amylin. It is used in patients who are being treated with insulin (type 1 and type 2 diabetics). It is given by injection at mealtimes. Akhilesh Bhambhani, C. Russell Middaugh, in Therapeutic Protein Drug Products, 2012
How does pramlintide work as an acetate salt?
Pramlintide is sold as an acetate salt. Pramlintide is an analogue of amylin, a small peptide hormone that is released into the bloodstream by the β cells of the pancreas along with insulin after a meal. Like insulin, amylin is completely absent in individuals with Type I diabetes.
How long does the effect of pramlintide last?
Pramlintide slows the rate at which food leaves the stomach to the small intestine following a meal and thus reduces the initial postprandial increase in plasma glucose. This effect lasts for approximately 3 hours following pramlintide administration.