What are examples of potassium channel blockers?
What are examples of potassium channel blockers?
Examples of voltage-gated channel blockers include:
- Some types of dendrotoxins.
- 3,4-Diaminopyridine (amifampridine)
- 4-Aminopyridine (fampridine/dalfampridine)
- Adekalant.
- Almokalant.
- Amiodarone.
- Azimilide.
- Bretylium.
What drug is a potassium channel blocker?
They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS. A potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS)….Potassium Channel Blockers.
| Drug | Target | Type |
|---|---|---|
| Amiodarone | HERG human cardiac K+ channel | target |
| Amiodarone | Cytochrome P450 2C8 | enzyme |
| Amiodarone | Cytochrome P450 2C9 | enzyme |
What happens when you inhibit potassium channels?
Potassium channels are also responsible for repolarizing slow-response action potentials in the sinoatrial and atrioventricular nodes. Therefore, blocking these channels slows (delays) repolarization, which leads to an increase in action potential duration and an increase in the effective refractory period (ERP).
What toxin blocks potassium channels?
Dendrotoxins
Dendrotoxins have been shown to block particular subtypes of voltage-gated potassium (K+) channels in neuronal tissue.
What do potassium channel blockers do to the heart?
The potassium channel blocker increases the duration of the absolute refractory period of both the atria and the ventricles; thus the action potential widens, slowing the frequency of depolarizations.
When should potassium channel blockers be used?
Potassium channel blockers are used to treat supraventricular and ventricular arrhythmias, life-threatening arrhythmias, and atrial fibrillation and flutter.
What triggers potassium channels to open?
Calcium-activated potassium channel – open in response to the presence of calcium ions or other signalling molecules. Inwardly rectifying potassium channel – passes current (positive charge) more easily in the inward direction (into the cell).
What is TTX poison?
Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin.
How do you get tetrodotoxin?
Food: Exposure to tetrodotoxin usually occurs through eating improperly prepared fish or possibly through contamination of other food products.