Does CCK stimulate gastric acid secretion?
Does CCK stimulate gastric acid secretion?
Effects of a CCK-A receptor antagonist on gastric acid secretion in man (abstr). Cholecystokinin both stimulates and inhibits gastric acid secretion in man (abstr).
Does CCK affect gastric motility?
CCK influences gastric motility, movements of the gastrointestinal tract that influence the passage of food. CCK stimulates contraction of the pyloric sphincter or pylorus.
How can we reduce motilin?
Intravenous injection of glucose, which increases the release of insulin, is also found to inhibit cyclic elevation of plasma motilin. Other studies on dogs have also suggested that motilin acted as endogenous ligand in positive feedback mechanism to stimulate the release of more motilin.
What triggers CCK?
The major nutrients that stimulate CCK release are fats and ingested proteins. Of these, the specific meal components that cause CCK release include fatty acids and amino acids. In some species, proteins appear to stimulate CCK secretion by virtue of their ability to inhibit intralumenal trypsin activity (20, 31).
What triggers the release of CCK?
Cholecystokinin is secreted by cells of the upper small intestine. Its secretion is stimulated by the introduction of hydrochloric acid, amino acids, or fatty acids into the stomach or duodenum. Cholecystokinin stimulates the gallbladder to contract and release stored bile into the intestine.
How does CCK affect motility?
We show that CCK modulates intestinal motility, having multiple effects on motility patterns depending on location in the gut and types of contractions. CCK reduced propagating contractions in the foregut, but it increased both non-propagating and propagating contractions in the hindgut.
Why does CCK decrease gastric motility?
Lipids and proteins induce CCK release from I cells in the duodenum and small intestine. CCK stimulates gallbladder contraction and pancreatic enzyme release via CCK1R. In addition, CCK inhibits gastric emptying and food intake through the vagal afferent neurons.
What hormones stimulate gastric emptying?
Gastrin is a hormone produced by the stomach, which stimulates the release of gastric acid.