Which of the following can be causes of hypocomplementemia?

Which of the following can be causes of hypocomplementemia?


  • Proteinuria.
  • Lupus Nephritis.
  • Lupus Vulgaris.
  • Membranoproliferative Glomerulonephritis.
  • Antigen Antibody Complex.
  • Sjoegren Syndrome.
  • Systemic Lupus Erythematosus.

Why is hypocomplementemia consistent with a diagnosis of SLE?

The diagnostic value of hypocomplementemia in patients with SLE is based on the association with disease activity, immune-complex mediated manifestations (glomerulonephritis, cryoglobulinemia) and APS- related features (livedo reticularis, hemolytic anemia and aPL).

What does hypocomplementemia mean?

Medical Definition of hypocomplementemia : an abnormal deficiency of complement in the blood.

What is C4 deficiency?

A deficiency in complement C4 levels has been linked to different forms of kidney disease and chronic hepatitis. It has also been found in a number of childhood diseases, including: Henoch-Schonlein purpura, a type of inflammation of the blood vessels. Childhood diabetes mellitus.

What is complement in the blood?

Complement is a blood test that measures the activity of certain proteins in the liquid portion of your blood. The complement system is a group of nearly 60 proteins that are in blood plasma or on the surface of some cells.

What is the most common complement deficiency?

C2 deficiency is the most common complement deficiency, with frequency estimates between 1 in 10,000 to 1 in 20,000 for homozygous C2-deficient patients.

What is a normal C4 level?

Normal Results Normal ranges for C4 is 15 to 45 milligrams per deciliter (mg/dL) (0.15 to 0.45 g/L).

What is the clinical significance of hypocomplementemia?

However, in interpreting the clinical significance of hypocomplementemia, the following must be kept in mind: 1) There are numerous non-immunologic conditions that also can c … Hypocomplementemia is an important marker for the presence of IC-mediated disease and can be used to assess disease activity.

Can a multisystem disease cause hypocomplementemia?

Furthermore, some of these conditions can cause a multisystem disease that, along with the hypocomplementemia, can closely resemble an IC-mediated systemic vasculitis.

How is CHSO used to diagnose hypocomplementemia?

Thus, the measurement of serum or plasma C3, C4 and CHSO is used commonly to assess for the presence of an IC-mediated disease or, in patients with a known IC disorder, to assess for disease activity [1). However, there are numerous non-immu- nologic conditions that also can cause hypocomplementemia. It

What causes loss of complement regulation in membranoproliferative glomerulonephritis?

In most patients, loss of complement regulation is caused by the C3 nephritic factor (C3NeF), an immunoglobulin (Ig)G autoantibody that binds and prevents the inactivation of C3 convertase (C3bBb) of the alternative pathway, thereby resulting in the perpetual breakdown of C3.