What is the action of insulin glargine?
Insulin glargine is a long-acting, manmade version of human insulin. Insulin glargine works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar.
What is the difference between glargine 100 and 300?
The new glargine-300 formulation was developed to have a flatter and more extended time-action profile than the original glargine-100, and these characteristics may translate into more stable and sustained glycemic control over a 24 h dosing interval.
How is glargine insulin calculated?
Our dose calculation formula is expressed as: [optimal daily dose of insulin glargine at 24 weeks] = starting dose (0.15×weight) + incremental dose (baseline HbA1c – target HbA1c+2).
How do you titrate insulin glargine?
Titrating Insulin Patients should titrate the dose 2 units at a time every two to three days, based on SMBG, until the FPG is at goal. A more aggressive starting dose for patients failing current therapy and an HbA1c above 8.5% would be 0.3 U/kg.
When should you take glargine?
The package insert for Lantus states that it should be administered once daily at bedtime. However, this product does exhibit a relatively constant glucose-lowering profile over 24 hours, and therefore in theory, time of dosing should not matter if administered at the same time daily.
What is U 300 insulin?
U300 insulin glargine is a concentrated insulin product that contains 300 units/mL of insulin glargine. This concentrated glargine product has a longer duration of action when compared with U100 insulin glargine (Lantus®). U300 insulin glargine is commercially available in disposable prefilled pens only .
What’s the difference between 100 and 300 ml of glargine?
Transferring from 100-unit/mL preparation to 300-unit/mL preparation of insulin glargine: Higher daily dosage of the 300-unit/mL preparation required to maintain same level of glycemic control.
What is the purpose of insulin glargine U-300?
Insulin Glargine U-300 (Toujeo) National Drug Monograph. VA Pharmacy Benefits Management Services, Medical Advisory Panel, and VISN Pharmacist Executives The purpose of VA PBM Services drug monographs is to provide a comprehensive drug review for making formulary decisions.
What is the recommended dosage of insulin glargine?
Recommended initial dosage of the 300-unit/mL preparation of insulin glargine is the same as that of the dosage of insulin being discontinued.
Are there antibodies in patients taking insulin glargine?
Insulin antibodies detected in patients receiving insulin glargine therapy during clinical trials.