What is Factor XII deficiency?
General Discussion. Summary. Factor XII deficiency is a rare genetic blood disorder that causes prolonged clotting (coagulation) of blood in a test tube without the presence of prolonged clinical bleeding tendencies. It is caused by a deficiency of the factor XII (Hageman factor), a plasma protein (glycoprotein).
Is Factor XII intrinsic?
Factor XII is part of the coagulation cascade and activates factor XI and prekallikrein in vitro. Factor XII itself is activated to factor XIIa by negatively charged surfaces, such as glass. This is the starting point of the intrinsic pathway.
What is factor XII activity?
Factor XII activity is determined utilizing an aPTT-based one-stage clotting time assay. Factor XII-depleted plasma is used as the substrate, and the clotting time with the patient plasma is compared to the clotting time of normal pooled plasma.
What are the 12 factors of blood clotting?
The following are coagulation factors and their common names:
- Factor I – fibrinogen.
- Factor II – prothrombin.
- Factor III – tissue thromboplastin (tissue factor)
- Factor IV – ionized calcium ( Ca++ )
- Factor V – labile factor or proaccelerin.
- Factor VI – unassigned.
- Factor VII – stable factor or proconvertin.
What disorder is associated with a deficiency of clotting factors?
Hemophilia is a rare disorder in which your blood doesn’t clot normally because it lacks sufficient blood-clotting proteins (clotting factors). If you have hemophilia, you may bleed for a longer time after an injury than you would if your blood clotted normally.
Is Factor 13 a hemophilia?
People who have severe hemophilia have less than one percent of active clotting factor in their blood. Factor XIII deficiency belongs to a group of rare forms of bleeding disorders; a group that includes deficiencies of fibrinogen, prothrombin and factors V, VII, and X.
What kind of disease is a factor XII deficiency?
Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting.
What is the role of factor XII in cats?
Factor XII is a plasma protein composed of 609 amino acids in cats. It is synthesized in the liver and circulates in the blood as an inactive precursor enzyme and contains two chains: a heavy chain and a light chain. This factor is involved in the clotting process and is thought to trigger the clotting cascade.
What kind of disorder is Hageman deficiency in cats?
Hageman deficiency is a blood clotting disorder characterized by deficiency in the coagulation factor XII. For more background information about blood coagulation as well as other haemophilia disorders, please read our blog Haemophilia in cats. Hageman is an autosomal recessive trait. The trait has been described in humans, cats and dogs.
Is there a link between factor XII deficiency and miscarriage?
There are also reports in the medical literature that suggest an association between factor XII deficiency and repeated unexplained miscarriages in some affected women. However, such an association remains controversial and unproven. Factor XII deficiency is inherited as an autosomal recessive disorder.