What is CTX in osteoporosis?
What is CTX in osteoporosis?
CTX — which stands for C-terminal cross-linked telopeptide — is an indicator of bone turnover. Turnover refers to the remodeling process by which bone is continually broken down (resorption) and built up (formation). Through this process, bone is strengthened and tiny fractures are repaired.
What does a high CTX mean?
increased bone resorption
Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.
What does CTX test for?
Serum cross-linked C-telopeptide of type I collagen (CTX) is a marker of osteoclast activity and is used to assess the level of bone resorption.
What is CTx level?
Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.
What is NTx blood test?
The NTx test measures the concentration of cross-linked N-telopeptides of type I collagen. 1. Levels of NTx correlate with the rate of bone resorption. 2,3. Bone resorption rates exceeding bone formation result in a net loss of bone and ultimately osteopenia or osteoporosis.
What is a good NTx score?
The reference ranges for NTX in urine, as measured in nm BCE/mm creatinine, are as follows : Male: 21-83. Female (premenopausal): 17-94. Female (postmenopausal): 26-124.
What is a CTx scan?
Collagen Type I C-Telopeptide (CTx) – CTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss.
What is normal NTX level?
The reference ranges for NTX in serum, as measured in nm BCE, are as follows : Male: 5.4-24.2. Female: 6.2-19.
Is bone resorption good or bad?
This is a natural process that’s important for your health and wellbeing. But when resorption happens at a higher rate than it can be replaced, it can lead to a decrease in your bone mass and put you at higher risk for fractures and breakage.
What is a bone marker test?
Bone markers are blood and urine tests that detect products of bone remodelling to help determine if the rate of bone resorption and/or formation is abnormally increased, suggesting a potential bone disorder.
What is NTx in bone?
The N-terminal telopeptide (NTX), also known as amino-terminal collagen crosslinks, is the N-terminal telopeptide of fibrillar collagens such as collagen type I and type II. It is used as a biomarker to measure the rate of bone turnover.
How is serum CTX used to monitor bone resorption?
Serum CrossLaps is a new assay for measuring carboxy-terminal collagen crosslinks (CTX) in serum. This measurement is reported to be more specific to bone resorption than other measurements. However, the utility of this and other markers in monitoring patients on antiresorptive therapy depends on ho …
Which is a new marker of bone resorption?
Serum CTX: a new marker of bone resorption that shows treatment effect more often than other markers because of low coefficient of variability and large changes with bisphosphonate therapy Serum CrossLaps is a new assay for measuring carboxy-terminal collagen crosslinks (CTX) in serum.
Can a bone marker be used to diagnose osteoporosis?
Although these markers are not currently recommended for use in the diagnosis of osteoporosis, they appear to be useful for the individual monitoring of osteoporotic patients treated with antiresorptive agents. [ 2] ( See the image below.) Prediction of bone loss with biochemical bone markers.
Is the NTX test based on a cross linking antibody?
The NTX test is based on an antibody against the N-terminal of collagen, including the cross-linking region; CTX is based on an antibody to an octapeptide at the C-terminal end.