What is C-myc gene expression?
What is C-myc gene expression?
c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time inhibiting expression of genes with antiproliferative functions. Because of its propensity to induce apoptosis, its expression is tightly regulated.
What is C-Myc and N myc?
Metabolism of Cell Growth and Proliferation The Myc proteins (c-Myc, L-Myc, S-Myc, and N-Myc) are a family of transcription factors that regulate growth and cell cycle entry by their ability to induce expression of genes required for these processes (44).
What cancer does C-MYC cause?
MYC is documented to be involved broadly in many cancers, in which its expression is estimated to be elevated or deregulated in up to 70% of human cancers. High levels of MYC expression have been linked to aggressive human prostate cancer and triple negative breast cancer (Gurel et al., 2008; Palaskas et al., 2011).
What regulates MYC expression?
Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival | Oncogene.
What is the role of MYC?
Function. Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs).
What does N-myc stand for?
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.
What is the purpose of MYC?
MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.
What cancers is MYC associated with?
In TCGA datasets, the amplification of Myc occurs in several cancer types, including breast, colorectal, pancreatic, gastric, and uterine cancers. In the experimental transformation process of normal cells into cancer cells, the MYC gene can cooperate with the RAS gene.
What does MYC gene stands for?
GeneCards Summary for MYC Gene MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement.
What does N myc gene do?
The MYCN gene is a member of the Myc family of oncogenes. These genes play important roles in regulating cell growth and division (proliferation) and the self-destruction of cells (apoptosis).
What happens to gene expression in the absence of Myc?
Genes for which expression is already significantly upregulated in the absence of Myc are strongly boosted in the presence of Myc, whereas genes for which expression is low in the absence Myc get only a small boost when Myc is present.
When does myc mRNA need to be translated into protein?
Myc mRNA contains an IRES (internal ribosome entry site) that allows the RNA to be translated into protein when 5′ cap -dependent translation is inhibited, such as during viral infection.
What is the function of lncRNA in c-Myc?
However, the function of lncRNA in the regulation of c-Myc oncogenic activity is still not well understood. Here, we report that as a transcriptional target of c-Myc, lncRNA E2F1 messenger RNA (mRNA) stabilizing factor regulates c-Myc function via modulating E2F1 mRNA stability.
How is c-Myc used as a transcription factor?
As a transcription factor, c-Myc, with its partner protein Max, is able to transcriptionally regulate target gene expression ( 6, 7 ). It has been previously shown that c-Myc controls the expression of 10 to 15% of genes in the genome. Recent studies also suggest c-Myc as a global amplifier of already active promoters ( 8, 9 ).