What is Bioisosterism in drug design?
What is Bioisosterism in drug design?
In drug design, the purpose of exchanging one bioisostere for another is to enhance the desired biological or physical properties of a compound without making significant changes in chemical structure. The main use of this term and its techniques are related to pharmaceutical sciences.
What do you mean by Bioisosterism?
Filters. (pharmacology) The relationship between bioisosteres, substituents or groups with similar physical or chemical properties that impart similar biological properties to a chemical compound. noun.
What is Isosterism and Bioisosterism?
Isosterism and Bioisosterism Replacement or modification of functional group with other group having similar properties is known as isosteric and bioisosteric replacement.
What is physicochemical properties of drugs?
DEFINITION: The ability of a chemical compound to elicit a pharmacological/ therapeutic effect is related to the influence of various physical and chemical (physicochemical) properties of the chemical substance on the bio molecule that it interacts with.
What is bioisosteric replacement?
A bioisosteric replacement transforms an active compound into another compound by exchanging a group of atoms with another, broadly similar group of atoms. Several computational methods have been described to automatically identify bioisosteric replacements.
Is used for Bioisosteric replacement of benzene?
1]pentane were validated as saturated bioisosteres for para-substituted benzenes in medicinal chemistry projects. It was shown that such replacement increases the water solubility, lowers lipophilicity and retains bioactivity of compounds.
What are classical Isosteres?
Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available. but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere.