What is bilateral generalized polymicrogyria?
Bilateral generalized polymicrogyria is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). This is the most widespread form of polymicrogyria and typically affects the entire surface of the brain.
Does polymicrogyria affect life expectancy?
The quality of life and life expectancy for people with BPP are not well-described but may depend on severity of symptoms, whether complications develop, and whether other birth defects or an underlying syndrome are present.
How is polymicrogyria causes?
There are several known causes for polymicrogyria. The most common of which results from the virus cytomegalovirus (CMV). Other causes include various prenatal infections, brain abnormalities, genetic disorders, and more. This condition may also result from brain injury while a baby is still in the womb.
Can polymicrogyria be cured?
Treatment. The Polymicrogyria (PMG) malformation cannot be reversed, but the symptoms can be treated. The removal of affected areas through hemispherectomy has been used in some cases to reduce the amount a seizure activity. Few patients are candidates for surgery.
What are the symptoms of polymicrogyria?
Signs and symptoms of these conditions can include recurrent seizures (epilepsy), delayed development, crossed eyes, problems with speech and swallowing, and muscle weakness or paralysis. The most severe form of the disorder, bilateral generalized polymicrogyria, affects the entire brain.
Is polymicrogyria a disability?
Polymicrogyria most often occurs as an isolated feature, although it can occur with other brain abnormalities. It is also a feature of several genetic syndromes characterized by intellectual disability and multiple birth defects.
What are symptoms of polymicrogyria?
Bilateral forms of polymicrogyria tend to cause more severe neurological problems. Signs and symptoms of these conditions can include recurrent seizures (epilepsy), delayed development, crossed eyes, problems with speech and swallowing, and muscle weakness or paralysis.
Is polymicrogyria a form of cerebral palsy?
Common problems associated with PMG in general are: swallowing and speech difficulties, reflux, seizures of varying degrees (about 90% are affect with seizures at some point in their lives), development delays, lack of muscle coordination, impaired cognition of varying degrees and cerebral palsy, but there can me many …
Is megalencephaly genetic?
Megalencephaly occurs when your brain produces too many new brain cells or cells that are too large. It can also occur when metabolic byproducts and matter build up in your brain. Genetic factors and genetic disorders can cause megalencephaly.
How does bilateral perisylvian polymicrogyria affect the brain?
Bilateral perisylvian polymicrogyria (BPP) is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). BPP is a subtype of a broader condition known as polymicrogyria. The cerebral cortex of the brain normally consists of several deep folds and grooves.
Are there any treatments for bilateral perisylvian polymicrogyria?
Treatment Treatment. Listen. The characteristics of the brain that define bilateral perisylvian polymicrogyria (BPP) cannot be corrected, but there are treatments or therapies that aim to improve the signs and symptoms of BPP. For example, anti-seizure medications may be prescribed to control seizures.
What kind of disease is congenital bilateral perisylvian syndrome?
Congenital bilateral perisylvian syndrome. Congenital bilateral perisylvian syndrome ( CBPS) is a rare neurological disease characterized by paralysis of certain facial muscles and epileptic seizures .
Which is the maximal region of the perisylvian polymicrogyria?
Polymicrogyria (an excessive number of small gyri or convolutions) that is maximal in perisylvian regions (the regions that surround the Sylvian fissures), which may be symmetric or asymmetric and may extend beyond perisylvian regions. The Sylvian fissures often extend posteriorly and superiorly.