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What does it mean to have high-grade squamous intraepithelial lesion?

What does it mean to have high-grade squamous intraepithelial lesion?

High-grade squamous intraepithelial lesion (HSIL) is a pre-cancerous disease that develops in the cervix. HSIL is called a pre-cancerous disease because over time it can turn into a type of cancer called squamous cell carcinoma.

What causes squamous intraepithelial lesion?

They are usually caused by infection with certain types of human papillomavirus (HPV) and are found when a Pap test or biopsy is done. Low-grade squamous intraepithelial lesions usually go away on their own without treatment, but sometimes they can become cancer and spread into nearby tissue.

How do you get rid of high-grade squamous intraepithelial lesions?

Excisional treatments for HSIL include:

  1. Loop Electrosurgical Excision Procedure (LEEP): During a LEEP, an electric current is sent through a wire loop.
  2. Conization: Also called a cone biopsy or cold knife ionization, conization removes a larger, cone-shaped sample of abnormal tissue.

Can high-grade squamous intraepithelial lesion go away?

Cervical dysplasia can range from mild to severe, depending on the appearance of the abnormal cells. On the Pap test report, this will be reported as a low- or high-grade squamous intraepithelial lesion (SIL) or sometimes as atypical squamous or glandular cells. Dysplasia could go away on its own.

How long does it take to get the results of a colposcopy?

Normal Results A specialist called a pathologist will examine the tissue sample from the cervical biopsy and send a report to your doctor. Biopsy results most often take 1 to 2 weeks. A normal result means there is no cancer and no abnormal changes were seen.

How are squamous intraepithelial lesions treated?

There are two ways to do this:

  1. Loop electrosurgical excision procedure (LEEP). Your doctor uses a thin wire with an electric current to remove the abnormal areas.
  2. Conization. Using a scalpel, your doctor removes a cone-shaped piece of the cervix where the abnormal cells were found.

How long does it take for LSIL to progress to HSIL?

high-grade squamous intraepithelial lesions (HSIL) In about 10 percent of cases, LSIL progresses to high-grade squamous intraepithelial lesions (HSIL) within two years.

What if my colposcopy results are bad?

Treatment Options After an Abnormal Pap Test When your colposcopy is complete and your biopsy results are finalized, your doctor will explain the changes in your tissue sample. Sometimes, those changes are low-grade. This means you can watch and wait. Low-grade cervical changes are unlikely to become cervical cancer.

What is a high grade Squamous Intraepithelial Lesion?

High grade squamous intraepithelial lesion (HSIL) is a squamous cell abnormality associated with human papillomavirus (HPV). It encompasses the previously used terms of CIN2, CIN3, moderate and severe dysplasia and carcinoma in situ. This current terminology for HSIL was introduced by the Bethesda S …

Can a high grade squamous lesion lead to cervical cancer?

High grade squamous intraepithelial lesion may eventually lead to invasive cancer of the cervix when managements are not instituted. Being carcinoma in situ, it is considered stage 0 cervical cancer, but may not indicate that there is already cervical cancer.

What are the grades of cervical intraepithelial neoplasia?

HSIL on a screening Pap smear usually corresponds to cervical intraepithelial neoplasia (CIN), which are precancerous cells that are graded based on how abnormal the cells appear under a microscope. The grades of CIN are: 5  CIN 1 (grade 1): Also called low-grade or mild dysplasia, there are slightly abnormal cells found on the cervix.

How does the squamous epithelium affect cellular maturation?

The squamous epithelium was thickened with decreased cellular maturation throughout and replete with decreased nuclear to cytoplasmic ratios, nuclear membrane atypia, nuclear hyperchromasia, and mitotic figures seen throughout the entire thickness of the epithelium Image 1.