What does HER2 borderline mean?
What does HER2 borderline mean?
The IHC gives a score of 0 to 3+ that measures the amount of HER2 proteins on the surface of cells in a breast cancer tissue sample. If the score is 0 to 1+, it’s considered HER2-negative. If the score is 2+, it’s considered borderline. A score of 3+ is considered HER2-positive.
Can HER2-positive become negative?
Your HER2 status can change as your cancer grows or returns. That is, HER2-positive cancer can become HER2-negative and vice versa. You and your doctor may decide to retest for HER2 over time or if your cancer comes back after treatment.
How do you read HER2 FISH results?
Answer
- Positive HER2 amplification: FISH ratio is greater than 2.2 or HER2 gene copy is greater than 6.0.
- Equivocal HER2 amplification: FISH ratio of 1.8-2.2 or HER2 gene copy of 4.0-6.0.
- Negative HER2 amplification: FISH ratio is less than 1.8 or HER2 gene copy of less than 4.0.
What does HER2 FISH positive mean?
FISH testing usually returns one of two results: positive or negative. Positive means your breast cancer cells make too much HER2 and your doctor should treat you with drugs that target that protein. Negative means the protein isn’t involved in the growth of your tumor.
When is HER2 repeated?
When 90% or more of the tumor shows one of these histologic patterns and the tumor is grade 1, HER2 testing does not need to be repeated if the initial HER2 test is negative, but if the initial test is positive, HER2 testing should be repeated due to low frequency of HER2 amplification or overexpression observed in …
How is HER2 status calculated?
Although complicated, HER2 status is basically determined by IHC results in the dual-probe ISH groups 2 to 4. While cases with HER2 IHC 3+ are regarded as HER2 positive, those with HER2 IHC 0 or 1+ are regarded as HER2 negative. In cases with HER2 IHC 2+, an additional observer blinded to previous result recounts ISH.
Is HER2 positive good?
About 25% of breast cancers are HER2-positive. HER2-positive cancers are a mix of good and bad news. The bad news is the tumors tend to grow more aggressively than those without the HER2 receptor. The good news is that like ER/PR-positive cancers, medicines can switch the HER2 growth receptor off.
What are the HER2 results for breast cancer?
Test Results IHC Result HER2 Overexpression Status 0 Negative 1+ Negative 2+ Borderline 3+ Positive
What happens when a HER2 test is inconclusive?
Inaccuracy (errors): Sometimes, test results are inconclusive. In these instances, testing another sample might be needed, which means patients must comply with repeat testing in order to get an accurate result. Heterogenicity: There may be parts of a tumor that test HER2-positive and others that test HER2-negative.
Can a HER2 positive tumor be a negative metastasis?
The chance of discordance between the original tumor and a first or second metastasis (either from negative to positive or from positive to negative) is as follows: In one 2016 study, almost 20 percent of tumors changed status from HER2-positive to HER2-negative, or vice versa.
Is the HER2 summary result required by NCI?
The HER2 summary result was not a required data item for all breast cancer cases diagnosed in 2010, even though most SEER registries collected, coded, and submitted such data to the NCI SEER program.