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What does Arthus reaction look like?

What does Arthus reaction look like?

The most common clinical manifestations of Arthus reaction are local tissue hardening, accompanied by obvious redness, swelling, and pain, diameter less than 5.0 cm at or around the site following the injection in mild cases, but in some severe cases the diameter of the redness or swelling can spread to the entire …

When does Arthus reaction occur?

Arthus reaction is a type of immune complex hypersensitivity reaction that can occur after vaccination. It is characterized by local site redness, warmness, swelling, or ulceration that usually occurs hours after vaccination. Arthus reaction is considered a type of cutaneous vasculitis.

What type of hypersensitivity is vaccine reaction?

Allergic responses caused by vaccines are generally of Type I and IV hypersensitivity reactions.

What is the difference between Arthus reaction and serum sickness?

Arthus reaction is caused due to the formation of antigen antibody complex which causes an inflammatory response. Serum sickness is also caused due to hypersensitivity created by antigen – antibody complex.

What is hypersensitivity and types?

Hypersensitivity reactions can be classified into four types. Type I – IgE mediated immediate reaction. Type II- Antibody-mediated cytotoxic reaction (IgG or IgM antibodies) Type III- Immune complex-mediated reaction. Type IV- Cell-mediated, delayed hypersensitivity reaction.

What is Arthur’s reaction?

Immune complexes form in the setting of high local concentration of vaccine antigens and high circulating antibody concentration. Arthus reactions are characterized by severe pain, swelling, induration, edema, hemorrhage, and occasionally by necrosis. These symptoms and signs usually occur 4–12 hours after vaccination.

What is delayed type hypersensitivity?

An inflammatory response that develops 24 to 72 hours after exposure to an antigen that the immune system recognizes as foreign. This type of immune response involves mainly T cells rather than antibodies (which are made by B cells). Also called DTH.