What does a high SCL 70 mean?

What does a high SCL 70 mean?

Serum anti-topoisomerase, also known as SCL-70, is specific to diffuse scleroderma (and the test is positive in 20% of people with scleroderma). Two-thirds of patients with this antibody have diffuse scleroderma. They also have pulmonary interstitial fibrosis and reduced survival.

Which is the significance of SCL 70 antibodies and anti centromere antibodies?

Anti-centromere antibodies (ACA) and anti-Scl-70 antibodies are very useful in distinguishing patients with systemic sclerosis (SSc) from healthy controls, from patients with other connective tissue disease, and from unaffected family members.

What does SCL 70 AB test for?

Autoantibodies against topoisomerase I (anti-Scl 70 antibodies) are the typical serologic marker of diffuse cutaneous systemic sclerosis (dcSSc). Systemic sclerosis (SSc) is a connective tissue disease characterized by microvascular damage and fibrosis of the skin and visceral organs.

Can you get a false positive SCL 70?

Scl-70 (topo-1) is a DNA binding protein and anti-DNA/DNA complexes in the sera of SLE patients may bind to topo-I, leading to a false-positive result. The presence of Scl-70 antibody in sera may also be due to contamination of recombinant Scl-70 with DNA derived from cellular material used in immunoassays.

What does a positive SCL 70 antibody mean?

A positive test result for Scl 70 antibodies is consistent with a diagnosis of scleroderma.

How much of Japan’s population live in cities?

The 2010 census shows 90.7% of the total Japanese population live in cities. Japan is an urban society with about only 5% of the labor force working in agriculture. Many farmers supplement their income with part-time jobs in nearby towns and cities.

Why does Japan have a high population concentration?

Japan has a high population concentration in urban areas on the plains since 75% of Japan’s land area is made up of mountains, and also Japan has a forest cover rate of 68.5% (the only other developed countries with such a high forest cover percentage are Finland and Sweden).

How often does the census take place in Japan?

Japan collects census information every five years, with censuses conducted by the Statistics Bureau of the Ministry of Internal Affairs. The latest population census reflects the situation as of 1 October 2015.

How many prefectures does Japan have in the world?

Out of 47 prefectures, 13 are red and 34 are green. The population of Japan has been decreasing since 2011. Only 8 prefectures had increased its population compared to 2010, due to internal migration to large cities.