What class of drug is tenecteplase?

What class of drug is tenecteplase?

Tenecteplase Overview Tenecteplase belongs to a group of drugs called thrombolytics. These work by breaking up or dissolving blood clots, which are the main cause of heart attacks. This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

What is tNK?

Tenecteplase (sold under the trade names TNKase and Metalyse) is an enzyme used as a thrombolytic drug. Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells).

What is IV thrombolytic?

Definition: Intravenous (IV) thrombolytic therapy was initiated at this hospital. IV thrombolytics convert plasminogen to plasmin, which in turn breaks down fibrin and fibrinogen, thereby dissolving thrombus. IV t-PA is the only FDA-approved IV thrombolytic for stroke.

What is the difference between alteplase and tenecteplase?

Alteplase remains the only FDA-approved thrombolytic for acute ischemic stroke. Tenecteplase, a modified tissue plasminogen activator, binds more selectively and has a longer half-life that allows it to be administered as a single bolus rather than the bolus and continuous infusion required for alteplase.

Is TNK FDA-approved?

To date, the only scientifically-proven and FDA-approved treatment for acute stroke is the clot-busting drug, tissue plasminogen activator (tPA). A newer clot-busting drug, tenecteplase (TNK), has chemical properties that make it a potentially safer and more effective drug for treating stroke.

What is TNK injection?

TENECTEPLASE (TEN neck te place) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack. COMMON BRAND NAME(S): TNKase.

Is aspirin a thrombolytic drug?

Thrombolytic agents are most often used in patients with coexisting cardiovascular medication, including various antihypertensives, beta-blocking agents, nitrates and aspirin (acetylsalicylic acid).

What drug is used for thrombolysis?

The most commonly used drug for thrombolytic therapy is tissue plasminogen activator (tPA), but other drugs can do the same thing. Ideally, you should receive thrombolytic medicines within the first 30 minutes after arriving at the hospital for treatment. A blood clot can block the arteries to the heart.

How is Metalyse used to treat blood clots?

With the blood clot broken down, blood can flow more easily into the heart muscle, allowing the heart to keep working and helping to save the patient’s life. Tenecteplase is made by a method known as ‘recombinant DNA technology’: it is made by a cell that has received a gene (DNA), which makes it able to produce it. How has Metalyse been studied?

What does Metalyse stand for in medical terms?

/te·nec·te·plase/ (tĕ-nek´tĕ-plās) a modified form of human tissue plasminogen activator produced by recombinant DNA technology; used as a thrombolytic agent in the treatment of myocardial infarction.

How is thrombolysis used to treat heart attacks?

Thrombolysis is often used as an emergency treatment to dissolve blood clotsthat form in arteriesfeeding the heartand brain– the main cause of heart attacksand ischemic strokes — and in the arteries of the lungs(acute pulmonary embolism). Thrombolysis is also used to treat blood clots in:

What are the medical conditions associated with thrombolytics?

Medical conditions associated with thrombolytics: Arterial Thrombosis. Deep Vein Thrombosis. Heart Attack. Ischemic Stroke. IV Catheter Clot. Pulmonary Embolism. Thrombotic/Thromboembolic Disorder.