What causes elevated aldolase?

What causes elevated aldolase?

Elevated aldolase is usually a sign of muscle or liver damage. For example, muscle damage from a heart attack releases aldolase in large quantities. Liver damage, such as hepatitis or cirrhosis, raises aldolase levels as well.

What is aldolase lab test for?

Aldolase levels in the blood rise when a person has muscle damage. The aldolase blood test may be ordered to diagnose and monitor certain conditions related to skeletal muscle. It largely has been replaced by other muscle enzyme tests, especially CK (creatine kinase).

What is considered a high aldolase level?

Generally, the normal range for adults is between 1.0 and 7.5 units per liter. The normal amount of aldolase in the blood is higher in children. For those under age 18, anything under 14.5 units per liter is considered normal.

What type of reaction is aldolase?

Aldolase is a glycolytic enzyme that catalyzes the conversion of fructose 1-6-diphosphate to glyceraldehyde 3-phosphate and dihydroxy-acetone phosphate via the glycolysis metabolic pathway. Within the cell, aldolase is localized in both the cytoplasm and nucleus.

What is a normal aldolase test?

Normal results range between 1.0 to 7.5 units per liter (0.02 to 0.13 microkat/L). There is a slight difference between men and women. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples.

What is the function of aldolase?

Aldolase is a cytoplasmic enzyme involved in glucose and fructose metabolism. It specifically catalyzes the reversible reaction of converting fructose 1,6-bisphosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehydes 3-phosphate. The enzyme works on six reversible reactions in gluconeogensis and glycolysis.

What is another name for aldolase?

Aldolase A (ALDOA, or ALDA), also known as fructose-bisphosphate aldolase, is an enzyme that in humans is encoded by the ALDOA gene on chromosome 16.

What is the normal range for aldolase?

Normal results range between 1.0 to 7.5 units per liter (0.02 to 0.13 microkat/L). There is a slight difference between men and women.

What is aldolase deficiency?

Aldolase A deficiency, is an autosomal recessive metabolic disorder resulting in a deficiency of the enzyme aldolase A; the enzyme is found predominantly in red blood cells and muscle tissue.

Why does aldolase B cause hypoglycemia?

In individuals deficient in aldolase B activity, this causes an accumulation of fructose-1-phosphate, leading to subsequent inhibition of both glycolytic and gluconeogenesis pathways, thus causing hypoglycemia in individuals.