What can I monitor with Imuran?
Laboratory Tests: Complete Blood Count (CBC) Monitoring: Patients on Imuran should have complete blood counts, including platelet counts, weekly during the first month, twice monthly for the second and third months of treatment, then monthly or more frequently if dosage alterations or other therapy changes are …
How is Imuran metabolized?
MECHANISM OF ACTION Azathioprine is metabolized in the liver before becoming active. One metabolic pathway is through its conversion to 6-mercaptopurine, the active metabolite of 6-mercaptopurine being 6-thioinosinic acid. Azathioprine also is metabolized by other pathways independently of 6-mercaptopurine.
Should Imuran be taken with food?
Azathioprine is best taken on an empty stomach, at least 1 hour before or 3 hours after food or milk. But if azathioprine makes you feel nauseous or sick, try taking it after food or at bedtime, or ask if you can divide your dose and take it twice a day. Swallow your tablets whole with a drink of water.
Can azathioprine be taken with milk?
Azathioprine may be taken with food or on an empty stomach, but patients should standardise the method of administration. The dose should not be taken with milk or dairy products (see Section 4.2).
How long should you take Imuran?
How long will I be taking it? If tolerated, you will probably be on azathioprine for up to 5 years. Do not stop taking your medicine unless your doctor tells you to, even if you feel well.
Does Imuran make you gain weight?
No, Imuran (azathioprine) itself is not causing your weight gain.
Is Imuran a high risk medication?
Patients receiving immunosuppressants, including IMURAN, are at increased risk of developing lymphoma and other malignancies, particularly of the skin. Physicians should inform patients of the risk of malignancy with IMURAN.
When to take azathioprine or Imuran after meals?
This may improve over time, and can get better when the drug is taken after meals or in divided doses. Itchy rashes, a sore mouth or throat and mouth ulcers may occur. Azathioprine may also irritate the liver. Azathioprine can lower your immune system and increase your risk of getting infections.
How much Imuran should I take for kidney transplant?
Renal Homotransplantation: The dose of Imuran required to prevent rejection and minimize toxicity will vary with individual patients; this necessitates careful management. The initial dose is usually 3 to 5 mg/kg daily, beginning at the time of transplant.
Is there a 5 year survival rate for Imuran?
IMURAN is indicated as an adjunct for the prevention of rejection in renal homotransplantation. Experience with over 16,000 transplants shows a 5-year patient survival of 35% to 55%, but this is dependent on donor, match for HLA antigens, anti-donor or anti-B-cell alloantigen antibody, and other variables.
When do platelet counts start to go up on Imuran?
Hematologic toxicities are dose-related and may be more severe in renal transplant patients whose homograft is undergoing rejection. It is suggested that patients on Imuran have complete blood counts, including platelet counts, weekly during the first month]